Dr. Vikramjeet Singh Senior Scientist
Institute for Experimental Immunology and Imaging
University Duisburg-Essen
Universitätstr. 2
45141 Essen, Germany
Publications (Recent 10 first/last author)
1. Tuz A, Ghosh S, Karsch L, Antler M, Lakovic V, Lohmann S, Lehmann A, Beer A, Nagel D, Jung M, Hörenbaum N, Kaygusuz V, Qefalia A, Alshaar B, Amookazemi N, Bolsega S, Basic M, Siveke J, Heiles S, Grüneboom A, Lueong S, Herz J, Sickmann A, Hagemann N, Hasenberg A, Hermann D, Gunzer M, Singh V. Gut microbiota deficiency reduces neutrophil activation and is protective after ischemic stroke. J Neuroinflammation 2025 May. With DFG funding.
2. Tuz A, Hoerenbaum N, Ulusoy Ö, Ahmadi A, Gerlach A, Beer A, Kraus A, Hasenberg A, Hagemann N, Hermann D, Gunzer M, Singh V. Hypercholesterolemia triggers innate immune dysbalance and transforms brain infarcts after ischemic stroke. Frontier Immunology, 2025 Jan. With DFG funding
3. Tuz A, Ghosh S, Gallert M, Ttoouli D, Hasenberg A, Sickmann A, Chen J, Hermann DM, …Gunzer M, Singh V. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion, Nature Cardiovascular Research, 2024 April. With DFG funding
4. Tuz A, Hasenberg A, Hermann M, Gunzer M, Singh V. Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery. Frontier
Immunology, 2022 Nov. With DFG funding
5. Singh V, Beer A, Kraus A, Mang F, Zhang X, Xue J, Hagemann N, Hermann DM, Gunzer M. Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs. Brain Behaviour Immunity, 2021 May. With DFG funding
6. Singh V, Sadler R, Stefannie Benakis C, Liesz A. The gut microbiota primes a cerebroprotective response after stroke. J Cereb Blood Flow Metab. 2018 Aug.
7. Sadler R*, Singh V*, Benakis C, Lopez D, Hünig T, Stecher B, Anrather J, Liesz A. Microbiota differences between commercial breeders impacts the post-stroke immune
response. Brain Behavior and immunity, 2017 Nov. * Equal contribution.
8. Singh V, Roth S, Llovera G, Sadler R, Prehn C, Garzetti D, Stecher B, Dichgans M, Liesz A. Microbiota dysbiosis controls the neuroinflammatory response after stroke. J of Neuroscience, 2016 July.
9. Singh V, Roth S, Veltkamp R, Liesz A. HMGB1 as a key mediator of immune mechanisms in ischemic stroke. Antioxidants and Redox Signaling, 2016 April.
10. Singh V, Bhatia HS, Kumar A, de Oliveira AC, Fiebich BL. Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharideactivated primary microglia. Neuroscience, 2014 April.
Publications (Recent 7 co-author)
1. Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, Zhao S, Al-Maskari R, Singh I, Ali M, Bhatia HS, Minde DP, Negwer M, Hoeher L, Calandra GM, Groschup B, Su J, Kimna C, Rong Z, Galensowske N, Todorov MI, Jeridi D, Ohn TL, Roth S, Simats A, Singh V, Khalin I, Pan C, Arús BA, Bruns OT, Zeidler R, Liesz A, Protzer U, Plesnila N, Ussar S, Hellal F, Paetzold J, Elsner M, Dietz H, Erturk A. Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning. Nature Biotechnology, 2025 Jan.
2. Richter M, Diesterbeck E, Pylaeva E, Labusek N, Köster C, Nagel D, Karsch L, Hagemann N……., Singh V, Hermann DM, Gunzer M, Jablonska J, Felderhoff-Müser U, Bendix I, Oliver Soehnlein O, Herz J. Neonatal hypoxic-ischemic brain injury sequentially recruits neutrophils with dichotomous phenotype and function. Nature Communications, 2025, In revision.
3. Susmita Ghosh, Ali Ata Tuz, Martin Stenzel, Singh V, Mathis Richter, Oliver Soehnlein, Emanuel Lange, Robert Heyer, Zülal Cibir, Alexander Beer, Marcel Jung, Dennis Nagel, Dirk M Hermann, Anja Hasenberg, Anika Grüneboom, Albert Sickmann, Matthias Gunzer. Proteomic characterization of 1,000 human and murine neutrophils freshly isolated from blood and sites of sterile inflammation. Molecular & Cellular Proteomics, 2024 Nov.
4. Dongpei Yin, Chen Wang, Singh V, Ali Ata Tuz, Thorsten R Doeppner, Matthias Gunzer, Dirk M Hermann. Delayed DNase-I Administration but Not Gasdermin-D Inhibition Induces Hemorrhagic Transformation After Transient Focal Cerebral Ischemia in Mice. Stroke, 2024 Nov.
5. Cibir Z, Hassel J, Sonneck J, Kowitz L, Beer A, Kraus A, Hallekamp G, Rosenkranz M, Raffelberg P, Olfen S, Smilowski K, Burkard R, Helfrich I, Tuz AA, Singh V, Ghosh S, Sickmann A, Klebl AK, Eickhoff JE, Klebl B, Seidl K, Chen J, Grabmaier A, Viga R, Gunzer M. ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis. Nature Communications, 2023 Dec.
6. Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021 April.
7. Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A. Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Science Translational Medicine. 2018 Mar.